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A Major Drug Interaction exists between carisoprodol and Vicodin. View detailed information regarding this drug interaction. Learn about drug interactions between carisoprodol oral and hydrocodone-acetaminophen oral and use the RxList drug interaction checker to check drug combinations. The Carisoprodol is a muscle relaxer I think, and it says to take one every night before bed. And then the hydrocodone is take 1 to 2 tablets every 4 to 6 ... Dr. Waghmarae responded: Soma (carisoprodol) hydrocodone. Firstly - both medications can and have been used together. ... Compare Carisoprodol vs. Hydrocodone, which is better for uses like: Back Pain. Compare head-to-head ratings, side effects, warnings, dosages, interactions and ... I have heard Hydrocodone + Carisoprodol (Soma) muscle relaxants make a good combo, but I want to be careful, since I know they are both CNS depressants...

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